snoring, inflammatory markers, adipokines and metabolic syndrome in apparently healthy chinese打鼾,炎症标记物,发病和代谢综合征在看似健康的中国.pdfVIP

Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese 1 2 1,3 1 4 1 1 1 Liang Sun , An Pan , Zhijie Yu , Huaixing Li , Aizhen Shi , Danxia Yu , Geng Zhang , Geng Zong , Yong 1 1 Liu , Xu Lin * 1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China, 2 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, 3 SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, 4 Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China Abstract Objective: Chronic low-grade inflammation and adipokines dysregulation are linked to mechanisms underscoring the pathogenesis of obesity-related metabolic disorders. Little is known about roles of these cytokines on the association between snoring and metabolic syndrome (MetS). We aimed to investigate whether a cluster of cytokines are related to snoring frequency and its association with MetS in apparently healthy Chinese. Methods: Current analyses used a population-based sample including 1059 Shanghai residents aged 35–54 years. Self- reported snoring frequency was classified as never, occasionally and regularly. Fasting plasma glucose, lipid profile, insulin, C-reactive protein, interleukin-6, interleukin-18, lipopolysaccharide binding protein, high-molecular-weight adiponectin and leptin were measured. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III crit