有哪些信誉好的足球投注网站small interfering rna against transcription factor stat6 leads to increased cholesterol synthesis in lung cancer cell lines小干扰rna对转录因子stat6导致胆固醇合成增加肺癌细胞系.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
small interfering rna against transcription factor stat6 leads to increased cholesterol synthesis in lung cancer cell lines小干扰rna对转录因子stat6导致胆固醇合成增加肺癌细胞系
Small Interfering RNA against Transcription Factor STAT6 Leads to Increased Cholesterol Synthesis in Lung Cancer Cell Lines . . Richa Dubey , Ravindresh Chhabra , Neeru Saini* Functional Genomics Unit, Institute of Genomics and Integrative Biology (CSIR), Delhi, India Abstract STAT6 transcription factor has become a potential molecule for therapeutic intervention because it regulates broad range of cellular processes in a large variety of cell types. Although some target genes and interacting partners of STAT6 have been identified, its exact mechanism of action needs to be elucidated. In this study, we sought to further characterize the molecular interactions, networks, and functions of STAT6 by profiling the mRNA expression of STAT6 silenced human lung cells (NCI-H460) using microarrays. Our analysis revealed 273 differentially expressed genes after STAT6 silencing. Analysis of the gene expression data with Ingenuity Pathway Analysis (IPA) software revealed Gene expression, Cell death, Lipid metabolism as the functions associated with highest rated network. Cholesterol biosynthesis was among the most enriched pathways in IPA as well as in PANTHER analysis. These results have been validated by real-time PCR and cholesterol assay using scrambled siRNA as a negative control. Similar findings were also observed with human type II pulmonary alveolar epithelial cells, A549. In the present study we have, for the first time, shown the inverse relationship of STAT6 with the cholesterol biosynthesis in lung cancer cells. The present findings are potentially significant to advance the understanding and design of therapeutics for the pathological conditions where both STAT6 and cholesterol biosynthesis are implicated viz. asthma, atherosclerosis etc
您可能关注的文档
- a comparison of affymetrix gene expression arrays比较基因表达affymetrix数组.pdf
- a trial of a job-specific workers' health surveillance program for construction workers study protocol审判工作特定的工人的健康监测项目为建筑工人研究协议.pdf
- a new estimate of afrotherian phylogeny based on simultaneous analysis of genomic, morphological, and fossil evidence一个新的估计afrotherian发展史同时基于基因组的分析,形态和化石证据.pdf
- a double epidemic model for the sars propagation双sars传播的流行病模型.pdf
- a decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators一套假的耐热性的子域名从鸡villin盔,估计比较不同的自由能.pdf
- a comparison of snps and microsatellites as linkage mapping markers lessons from the zebra finch (taeniopygia guttata)比较单核苷酸多态性和微卫星链接映射标记教训斑胸草雀(taeniopygia guttata).pdf
- a plasmid-based system for expressing small interfering rna libraries in mammalian cellsplasmid-based系统小干扰rna表达在哺乳动物细胞库.pdf
- a correlated motif approach for finding short linear motifs from protein interaction networks相关主题的方法寻找短线性图案从蛋白质相互作用网络.pdf
- alternative splicing of tgf-betas and their high-affinity receptors tβri, tβrii and tβriii (betaglycan) reveal new variants in human prostatic cells可变剪接及和它们的高亲和性受体tβri tβrii和tβriii(betaglycan)揭示人类前列腺细胞的新变种.pdf
- adherence to prescribed oral medication in adult patients undergoing chronic hemodialysis a critical review of the literature遵守规定的口服药物治疗成人慢性血液透析患者接受一个关键文献之回顾.pdf
- small protein-mediated quorum sensing in a gram-negative bacterium小protein-mediated革兰氏阴性细菌群体感应.pdf
- small rna regulation of ovule development in the cotton plant, g. hirsutum l小rna调控棉花胚珠发育的植物,g分子l.pdf
- small ribosomal protein rps0 stimulates translation initiation by mediating 40s-binding of eif3 via its direct contact with the eif3atif32 subunit小核糖体蛋白rps0刺激翻译起始的调停40 s-binding eif3 eif3atif32亚基通过直接接触.pdf
- small rnas with 5′-polyphosphate termini associate with a piwi-related protein and regulate gene expression in the single-celled eukaryote entamoeba histolytica小rna 5u2032多磷酸盐末端与piwi-related蛋白和调节基因的表达在单细胞真核痢疾阿米巴.pdf
- small volume dissolution testing as a powerful method during pharmaceutical development体积小解散测试是一个强大的方法在药物开发.pdf
- small variable segments constitute a major type of diversity of bacterial genomes at the species level小变量部分构成一个主要类型的细菌基因组的多样性物种水平.pdf
- small volume of hypertonic saline as the initial fluid replacement in experimental hypodynamic sepsis体积小的高渗盐水作为初始流体替代实验衰弱的脓毒症.pdf
- small-bodied humans from palau, micronesia小的人类从帕劳群岛、密克罗尼西亚.pdf
- small studies may overestimate the effect sizes in critical care meta-analyses a meta-epidemiological study小研究可能高估了尺度效应在危重病荟萃分析meta-epidemiological研究.pdf
- small-scale fisheries bycatch jeopardizes endangered pacific loggerhead turtles太平洋小规模渔业捕获危害濒危的海龟.pdf
文档评论（0）