small gtp-binding protein rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts小gtp-binding蛋白质rho-mediated信号促进类风湿性滑膜成纤维细胞的增殖.pdfVIP
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small gtp-binding protein rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts小gtp-binding蛋白质rho-mediated信号促进类风湿性滑膜成纤维细胞的增殖
Available online /content/7/3/R476 Vol 7 No 3 Open Access Research article Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts 1 2 1 3 1 Shingo Nakayamada , Hitoshi Kurose , Kazuyoshi Saito , Akira Mogami and Yoshiya Tanaka 1First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan 2Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan 3Pharmaceuticals Research Unit, Research Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan Corresponding author: Yoshiya Tanaka, tanaka@med.uoeh-u.ac.jp Received: 11 Nov 2004 Revisions requested: 24 Nov 2004 Revisions received: 10 Jan 2005 Accepted: 18 Jan 2005 Published: 18 Feb 2005 Arthritis Research Therapy 2005, 7:R476-R484 (DOI 10.1186/ar1694) /content/7/3/R476 © 2005 Nakayamada et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Rho is a major small GTP-binding protein that is involved in the signaling domain of p115RhoGEF) and by the C-terminal regulation of various cell functions, including proliferation and fragments of Gα13 (an inhi
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