slip-sliding away serial changes and homoplasy in repeat number in the drosophila yakuba homolog of human cancer susceptibility gene brca2slip-sliding连续变化和类似的重复数量果蝇yakuba同族体的人类癌症易感性brca2基因.pdfVIP

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slip-sliding away serial changes and homoplasy in repeat number in the drosophila yakuba homolog of human cancer susceptibility gene brca2slip-sliding连续变化和类似的重复数量果蝇yakuba同族体的人类癌症易感性brca2基因.pdf

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slip-sliding away serial changes and homoplasy in repeat number in the drosophila yakuba homolog of human cancer susceptibility gene brca2slip-sliding连续变化和类似的重复数量果蝇yakuba同族体的人类癌症易感性brca2基因

Slip-Sliding Away: Serial Changes and Homoplasy in Repeat Number in the Drosophila yakuba Homolog of Human Cancer Susceptibility Gene BRCA2 Sarah M. Bennett, John M. Mercer, Mohamed A. F. Noor* Biology Department, Duke University, Durham, North Carolina, United States of America Abstract Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51- binding BRC-repeat array in the ancestor of Drosophila yakuba. In this study, we examine patterns of variation and evolution of the dmbrca2 BRC-repeat array within D. yakuba and its close relatives. We develop a model of how unequal crossing over may have produced the expanded form, but we also observe short repeat forms, typical of other species in the D. melanogaster group, segregating within D. yakuba and D. santomea. These short forms do not appear to be identical-by-descent, suggesting that the history of dmbrca2 in the D. melanogaster subgroup has involved repeat unit contractions resulting in homoplasious forms. We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species. Citation: Bennett SM, Mercer JM, Noor MAF (2010) Slip-Sliding Away: Serial Changes and Homoplasy in Repeat Number in the Drosophila yakuba Homolog of Human Cancer Susceptibility Gene BRCA2. PLoS ONE 5(6): e11006. doi:10.1371/journal.pone.0011006 Editor: William J. Murphy, Texas AM University, United States of America Received April 20, 2010; Accepted May 17, 2010; Published June 8, 2010 Copyright: 2010 Bennett et al. This is an open-access article distributed under the terms of the Cr