skin prick testing does not reflect the presence of ige against food allergens in adult eosinophilic esophagitis patients a case study皮肤刺痛测试不能反映ige的存在对食物过敏原成人嗜酸性食管炎患者一个案例研究.pdfVIP

Kamdar et al. Clinical and Molecular Allergy 2010, 8:16 /content/8/1/16 CMA CASE REPORT Open Access Skin prick testing does not reflect the presence of IgE against food allergens in adult eosinophilic esophagitis patients: a case study * Toral A Kamdar, Anne M Ditto, Paul J Bryce Abstract Skin prick testing is widely used to predict the presence of allergen-specific IgE. In eosinophilic esophagitis patients, who frequently exhibit polysensitization and broad reactivity upon skin prick testing, this is commonly used to aid avoidance recommendations in the clinical management of their disease. We present here the predic- tive value of skin prick testing for the presence of allergen-specific IgE, in 12 patients, determined by immunoblot against the allergen extracts using individual-matched serum. Our results demonstrate a high degree of predictive value for aeroallergens but a poor predictive value for food allergens. This suggests that skin prick testing likely identifies IgE reactivity towards aeroallergens in adult eosinophilic esophagitis but this is not true for foods. Consequently, IgE immunoblotting might be required for determining food avoidance in these patients. Background and one food allergen. None of the patients has a his- Eosinophilic esophagitis (EoE) is a gastrointestinal disor- tory of IgE-mediated food allergy and, instead had been der that is associated with allergic disease. Studies have determined as EoE patients due to a history of dyspha- described personal or family histories of asthma or aller- gia, presence of endoscopic characteristics (e