sirtuin 1 regulates srebp-1c expression in a lxr-dependent manner in skeletal musclesirtuin蛋白1调节srebp-1c lxr-dependent的方式表达骨骼肌.pdfVIP
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sirtuin 1 regulates srebp-1c expression in a lxr-dependent manner in skeletal musclesirtuin蛋白1调节srebp-1c lxr-dependent的方式表达骨骼肌
Sirtuin 1 Regulates SREBP-1c Expression in a LXR- Dependent Manner in Skeletal Muscle ´ 1 2 ´ 1 3 1 Aurelia Defour , Kevin Dessalle , Andrea Castro Perez , Thomas Poyot , Josiane Castells , Yann 1 2 2 4 ´ 5 ´ 3 Simon Gallot , Christine Durand , Vanessa Euthine , Yansong Gu , Daniel Bechet , Andre Peinnequin , 2 1 Etienne Lefai , Damien Freyssenet * ´ ´ 1 Laboratoire de Physiologie de l’Exercice, Universite de Lyon, Saint Etienne, France, 2 Laboratoire CarMeN, INSERM U1060, INRA 1235, Universite de Lyon, Oullins, France, ˆ ´ ´ ´ ´ ´ 3 Pole de Genomique, Institut de Recherche Biomedicale des Armees, Centre de Recherche du Service de Sante des Armees, La Tronche, France, 4 Obenomics, Inc., ´ ` Bellevue, Washington, United States of America, 5 INRA UMR 1019, Unite Nutrition Humaine, St Genes Champanelle, France Abstract + Sirtuin 1 (SIRT1), a NAD -dependent protein deacetylase, has emerged as a main determinant of whole body homeostasis in mammals by regulating a large spectrum of transcriptional regulators in metabolically relevant tissue such as liver, adipose tissue and skeletal muscle. Sterol regulatory element binding protein (SREBP)-1c is a transcription fac
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