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BMC Urology BioMed Central Software Open Access A simple computer program for calculating PSA recurrence in prostate cancer patients Zhongyue Liao1,2 and Milton W Datta*2 Address: 1Bioinformatics Program Medical College of Wisconsin, Milwaukee, WI, 53226, U.S.A and 2Department of Pathology Medical College of Wisconsin, Milwaukee, WI, 53226, U.S.A Email: Zhongyue Liao - zliao@; Milton W Datta* - mdatta@ * Corresponding author Published: 19 June 2004 Received: 03 March 2004 Accepted: 19 June 2004 BMC Urology 2004, 4:8 This article is available from: /1471-2490/4/8 © 2004 Liao and Datta; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Prostate cancer is the most common tumor in men. The most commonly used diagnostic and tumor recurrence marker is Prostate Specific Antigen (PSA). After surgical removal or radiation treatment, PSA levels drop (PSA nadir) and subsequent elevated or increased PSA levels are indicative of recurrent disease (PSA recurrence). For clinical follow-up and local care PSA nadir and recurrence is often hand calculated for patients, which can result in the application of heterogeneous criteria. For large datasets of prostate cancer patients used in clinical studies PSA measurements are used as surrogate measures of disease progression. In t