基于表观遗传学肿瘤化学预防.PDF

国际病理科学与临床杂志 2013, 33(3) 218 Int J Path ol Clin Me d DOI:10.3969/j.issn.1673-2588.2013.03.008 ·综 述 · /gjblkx/fileup/PDF/201303218.pdf 基于表观遗传学的肿瘤化学预防 董欣1,2,3 ，肖兰博1,2,3 综述，曹亚1,2,3 审校 (1. 中南大学肿瘤研究所；2. 卫生部癌变原理重点实验室；3. 教育部癌变与侵袭原理重点实验室，长沙 410078) [摘　要] DNA 甲基化是表观遗传学的重要部分，同组蛋白修饰相互作用，通过改变染色质结构，调控基因 表达。在哺乳类细胞或人体细胞中，DNA 甲基化与细胞的增殖、衰老、癌变等生命现象有着重大 关系。以 DNA 甲基化作为切入点，总结近年来关于饮食化合物对表观遗传学调控的新进展，并阐 述抑制 DNA 甲基化或组蛋白去乙酰化的作用来发挥其对肿瘤的化学预防作用。 [关键词] 表观遗传学；DNA 甲基化；饮食化合物；化学预防 Cancer chemoprevention based on the epigenetics 1,2,3 1,2,3 1,2,3 DONG Xin , XIAO Lanbo , CAO Ya (1. Cancer Research Institute, Central South University; 2. Key Laboratory of Carcinogenesis of Ministry of Public Health; 3. Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Changsha 410078, China) Abstract DNA methylation is an important part of epigenetics, which includes the interaction with histone modification, the change of the chromatin structure, and the regulation of gene expression. In mammalian cells of human, DNA methylation is closely related to life phenomenon such as cell proliferation, senescence and canceration. Based on DNA methylation, this review summarized recent advances on the role of diet compounds in regulation of epigengtics. Cancer chemoprevention through inhibition of DNA methylation or histone acetylation has also been discussed. Key words epegenetics; DNA methylation;