antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2包膜糖蛋白抗体促进未成熟的登革2型病毒的传染性.pdfVIP
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antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2包膜糖蛋白抗体促进未成熟的登革2型病毒的传染性
Antibodies against the Envelope Glycoprotein Promote
Infectivity of Immature Dengue Virus Serotype 2
´ 1 1 ˜ 1
Julia M. da Silva Voorham , Izabela A. Rodenhuis-Zybert , Nilda Vanesa Ayala Nunez , Tonya M.
2 1 2 3 1
Colpitts , Heidi van der Ende-Metselaar , Erol Fikrig , Michael S. Diamond , Jan Wilschut , Jolanda M.
Smit1*
1 Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands,
2 Department of Medicine, Section of Infectious Diseases, Medical Institute Yale University School of Medicine, New Haven, Connecticut, United States of America,
3 Department of Molecular Microbiology, and Pathology Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Abstract
Cross-reactive dengue virus (DENV) antibodies directed against the envelope (E) and precursor membrane (prM) proteins
are believed to contribute to the development of severe dengue disease by facilitating antibody-dependent enhancement
of infection. We and others recently demonstrated that anti-prM antibodies render essentially non-infectious immature
DENV infectious in Fcc-receptor-expressing cells. Immature DENV particles are abundantly present in standard (st) virus
preparations due to inefficient processing of prM to M during virus maturation. Structural analysis has revealed that the E
protein is exposed in immature particles and this prompted us to investigate whether antibodies to E render immature
particles infectious. To this end, we analyzed the enhancing proper
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