amino-acid co-variation in hiv-1 gag subtype c hla-mediated selection pressure and compensatory dynamics在hiv - 1氨基酸共变gag c亚型hla-mediated选择压力和动态补偿.pdfVIP

Amino-Acid Co-Variation in HIV-1 Gag Subtype C: HLA-Mediated Selection Pressure and Compensatory Dynamics 1 3 1 1 Morgane Rolland *, Jonathan M. Carlson , Siriphan Manocheewa , J. Victor Swain , Erinn Lanxon- 1 1 1¤a 1 1 Cookson , Wenjie Deng , Christine M. Rousseau , Dana N. Raugi , Gerald H. Learn , Brandon S. 1 4 4 4,5,6 6,7 Maust , Hoosen Coovadia , Thumbi Ndung’u , Philip J. R. Goulder , Bruce D. Walker , Christian 6¤b 3 1,2 Brander , David E. Heckerman , James I. Mullins 1 Department of Microbiology, University of Washington, Seattle, Washington, United States of America, 2 Department of Medicine, University of Washington, Seattle, Washington, United States of America, 3 Microsoft Research, Redmond, Washington, United States of America, 4 HIV Pathogenesis Program, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, 5 Department of Pediatrics, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom, 6 Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 7 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America Abstract Background: Despite high potential for HIV-1 genetic variation, the emergence of some mutations is constrained by fitness costs, and may be associated with compensatory amino acid (A