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amino acid patterns around disulfide bonds氨基酸模式在二硫键
Int. J. Mol. Sci. 2010, 11, 4673-4686; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Amino Acid Patterns around Disulfide Bonds
José R. F. Marques 1, Rute R. da Fonseca 2, Brett Drury 3 and André Melo 1,*
1 REQUIMTE/Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do
Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal; E-Mail: zerui.marques@fc.up.pt
2 CIMAR/CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do
Porto, Rua dos Bragas, 177, 4050-123 Porto, Portugal; E-Mail: rute.r.da.fonseca@
3 LIAAD-INESC, Rua de Ceuta, 118, 6º, 4050-190 Porto, Portugal; E-Mail: brett.drury@
* Author to whom correspondence should be addressed; E-Mail: asmelo@fc.up.pt;
Tel.: +351-220402503; Fax: +351-220402659.
Received: 1 7 October 2010; in revised form: 4 November 2010 / Accepted: 11 November 2010 /
Published: 18 November 2010
Abstract: Disulfide bonds provide an inexhaustible source of information on molecular
evolution and biological specificity. In this work, we described the amino acid composition
around disulfide bonds in a set of disulfide-rich proteins using appropriate descriptors,
based on ANOVA (for all twenty natural amino acids or classes of amino acids clustered
according to their chemical similarities) and Scheffé (for the disulfide-rich proteins
superfamilies)
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