aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice气溶胶交付的小发夹骨桥蛋白块肺转移乳腺癌的老鼠.pdfVIP

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aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice气溶胶交付的小发夹骨桥蛋白块肺转移乳腺癌的老鼠.pdf

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aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice气溶胶交付的小发夹骨桥蛋白块肺转移乳腺癌的老鼠

Aerosol Delivery of Small Hairpin Osteopontin Blocks Pulmonary Metastasis of Breast Cancer in Mice 1 1 1 1 1 Kyeong-Nam Yu , Arash Minai-Tehrani , Seung-Hee Chang , Soon-Kyung Hwang , Seong-Ho Hong , Ji- 1,2 1 1 1,2 1 1 1 Eun Kim , Ji-Young Shin , Sung-Jin Park , Ji-Hye Kim , Jung-Taek Kwon , Hu-Lin Jiang , Bitna Kang , 4 4 5 6 7 Duyeol Kim , Chan-Hee Chae , Kee-Ho Lee , Tae-Jong Yoon , George R. Beck Jr. , Myung-Haing Cho1,2,3* 1 Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, 2 Department of Nano Fusion Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea, 3 Graduate Group of Tumor Biology, Seoul National University, Seoul, Republic of Korea, 4 Laboratory of Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea, 5 Laboratory of Molecular Oncology, Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, 6 Department of Applied BioScience, CHA University, Seoul, Republic of Korea, 7 Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia, United States of America Abstract Background: Metastasis to the lung may be the final step in the breast cancer-related morbidity. Conventional therapies such as chemotherapy and surgery are somewhat successful, however, metastasis-related breast can