a systematic molecular pathology study of a laboratory confirmed h5n1 human case系统的分子病理学研究实验室确认的h5n1禽流感人间病例.pdfVIP

A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case 1 1 1 1 1 2 2 Rongbao Gao , Libo Dong , Jie Dong , Leying Wen , Ye Zhang , Hongjie Yu , Zijian Feng , Minmei 3 3 3 4 4 5 6 1 Chen , Yi Tan , Zhaojun Mo , Haiyan Liu , Yunyan Fan , Kunxiong Li , Chris Ka-Fai Li , Dexin Li , 2 1 Weizhong Yang , Yuelong Shu * 1 Department of Influenza, Chinese National Influenza Center, State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China, 2 Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China, 3 Department of Infectious Diseases, Center for Disease Control and Prevention of Guangxi Zhuang Autonomous Region, Nanning, China, 4 Department of Infectious Diseases, Nanning City Center for Disease Control and Prevention, Nanning, China, 5 First Affiliated Hospital of Guangxi Medical University, Nanning, China, 6 MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom Abstract Autopsy studies have shown that human highly pathogenic avian influenza virus (H5N1) can infect multiple human organs other than just the lungs, and that possible causes of organ damage are either viral replication and/or dysregulation of cytokines and chemokines. Uncertainty still exists, partly because of the limited number of cases analysed. In this study, a full autopsy including 5