有哪些信誉好的足球投注网站a role for drosophila dfoxo and dfoxo 5′utr internal ribosomal entry sites during fasting一个角色为果蝇dfoxo dfoxo 5u2032utr禁食期间内部核糖体进入位点.pdfVIP
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a role for drosophila dfoxo and dfoxo 5′utr internal ribosomal entry sites during fasting一个角色为果蝇dfoxo dfoxo 5u2032utr禁食期间内部核糖体进入位点
A Role for Drosophila dFoxO and dFoxO 59UTR Internal
Ribosomal Entry Sites during Fasting
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Eugenia Villa-Cuesta* , Brian T. Sage, Marc Tatar
Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, United States of America
Abstract
One way animals may cope with nutrient deprivation is to broadly repress translation by inhibiting 59-cap initiation.
However, under these conditions specific proteins remain essential to survival during fasting. Such peptides may be
translated through initiation at 5 9UTR Internal Ribosome Entry Sites (IRES). Here we show that the Drosophila melanogaster
Forkhead box type O (dFoxO) transcription factor is required for adult survival during fasting, and that the 59UTR of dfoxO
has the ability to initiate IRES-mediated translation in cell culture. Previous work has shown that insulin negatively regulates
dFoxO through AKT-mediated phosphorylation while dFoxO itself induces transcription of the insulin receptor dInR, which
also harbors IRES. Here we report that IRES-mediated translation of both dFoxO and dInR is activated in fasted Drosophila S2
cells at a time when cap-dependent translation is reduced. IRES mediated translation of dFoxO and dInR may be essential to
ensure function and sensitivity of the insulin signaling pathway during fasting.
Citation: Villa-Cuesta E, Sage BT, Tatar M (2010) A Role for Drosophila dFoxO and dFoxO 5 9UTR Internal Ribosomal Entry Sites during Fasting. PLoS ONE 5(7):
e11521. doi:10.1371/journal.pone.0011521
Editor: Matt Kaeberlein, University of Washington, United States of America
Received March 15, 2010; Accepted June 16, 2010; Published July 9, 2010
Copyright: 2010 Villa-Cuesta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted u
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