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a plant virus movement protein regulates the gcn2p kinase in budding yeast植物病毒运动蛋白调节gcn2p激酶在出芽酵母
A Plant Virus Movement Protein Regulates the Gcn2p
Kinase in Budding Yeast
´
´ ´ ´ ´
Frederic Aparicio, Rafael Aparicio-Sanchis, Jose Gadea, Jesus Angel Sanchez-Navarro, Vicente Pallas,
´ ´ ´
Jose Ramon Murguıa*
´
Department of Stress Biology, Instituto de Biologıa Molecular y Celular de Plantas (UPV-CSIC), Valencia, Spain
Abstract
Virus life cycle heavily depends on their ability to command the host machinery in order to translate their genomes. Animal
viruses have been shown to interfere with host translation machinery by expressing viral proteins that either maintain or
inhibit eIF2a function by phosphorylation. However, this interference mechanism has not been described for any plant virus
yet. Prunnus necrotic ringspot virus (PNRSV) is a serious pathogen of cultivated stone fruit trees. The movement protein (MP)
of PNRSV is necessary for the cell-to-cell movement of the virus. By using a yeast-based approach we have found that over-
expression of the PNRSV MP caused a severe growth defect in yeast cells. cDNA microarrays analysis carried out to
characterise at the molecular level the growth interference phenotype reported the induction of genes related to amino
acid deprivation suggesting that expression of MP activates the GCN pathway in yeast cells. Accordingly, PNRSV MP
triggered activation of the Gcn2p kinase, as judged by increased eIF2a phosphorylation. Activation of Gcn2p by MP
expression required a functional Tor1p kinase, since rapamycin treatment al
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