a functional neuroimaging study of sound localization visual cortex activity predicts performance in early-blind individuals声音定位的功能性神经成像研究视觉皮层活动预计在早期个人的表现.pdfVIP

Open access, freely available online PLoS BIOLOGY A Functional Neuroimaging Study of Sound Localization: Visual Cortex Activity Predicts Performance in Early-Blind Individuals ´ ´ 1 2 1 1 1,3* Frederic Gougoux , Robert J. Zatorre , Maryse Lassonde , Patrice Voss , Franco Lepore ´ ´ ´ ´ ´ 1 Centre de Recherche en Neuropsychologie et Cognition, Departement de Psychologie, Universite de Montreal, Montreal, Quebec, Canada, 2 Neuropsychology/Cognitive ´ ´ ´ ´ ´ Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, 3 Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada Blind individuals often demonstrate enhanced nonvisual perceptual abilities. However, the neural substrate that underlies this improved performance remains to be fully understood. An earlier behavioral study demonstrated that some early-blind people localize sounds more accurately than sighted controls using monaural cues. In order to investigate the neural basis of these behavioral differences in humans, we carried out functional imaging studies using positron emission tomography and a speaker array that permitted pseudo-free-field presentations within the scanner. During binaural sound localization, a sighted control group showed decreased cerebral blood flow in the occipital lobe, which was not seen in early-blind individuals. During monaural sound localization (one ear plugged), the subgroup of early-blind subjects who were behaviorall