有哪些信誉好的足球投注网站a directed rnai screen based on larval growth arrest reveals new modifiers of c. elegans insulin signaling导演rnai屏幕基于秀丽隐杆线虫幼虫增长逮捕揭示新的修饰符的胰岛素信号.pdfVIP
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a directed rnai screen based on larval growth arrest reveals new modifiers of c. elegans insulin signaling导演rnai屏幕基于秀丽隐杆线虫幼虫增长逮捕揭示新的修饰符的胰岛素信号
A Directed RNAi Screen Based on Larval Growth Arrest
Reveals New Modifiers of C. elegans Insulin Signaling
Ola Billing., Balasubramanian Natarajan., Ateequrrahman Mohammed, Peter Naredi*, Gautam Kao*
˚ ˚
Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden
Abstract
Genes regulating Caenorhabditis elegans insulin/IGF signaling (IIS) have largely been identified on the basis of their
involvement in dauer development or longevity. A third IIS phenotype is the first larval stage (L1) diapause, which is also
influenced by asna-1, a regulator of DAF-28/insulin secretion. We reasoned that new regulators of IIS strength might be
identified in screens based on the L1 diapause and the asna-1 phenotype. Eighty- six genes were selected for analysis by virtue
of their predicted interaction with ASNA-1 and screened for asna-1-like larval arrest. ykt-6, mrps-2, mrps-10 and mrpl-43 were
identified as genes which, when inactivated, caused larval arrest without any associated feeding defects. Several tests
indicated that IIS strength was weaker and that insulin secretion was defective in these animals. This study highlights the role
of the Golgi network and the mitochondria in insulin secretion and provides a new list of genes that modulate IIS in C. elegans.
Citation: Billing O, Natarajan B, Mohammed A, Naredi P, Kao G (2012) A Directed RNAi Screen Based on Larval Growth Arrest Reveals New Modifiers of C. elegans
Insulin Signaling. PLoS ONE 7(4): e34507. doi:10.1371/journal.pone.0034507
Editor: Bob Goldstein, University of North Carolina at Chapel Hill, United States of America
Received November 25, 2011; Accepted March 6, 2012; Published April 12, 2012
Copyright: 2012 Billing et al. This is an open-access article dist
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