有哪些信誉好的足球投注网站a comparison of the crystal structures of eukaryotic and bacterial ssu ribosomal rnas reveals common structural features in the hypervariable regions比较真核和细菌晶体结构的半导体存储器核糖体rna揭示变异度高的地区常见的结构特点.pdfVIP
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a comparison of the crystal structures of eukaryotic and bacterial ssu ribosomal rnas reveals common structural features in the hypervariable regions比较真核和细菌晶体结构的半导体存储器核糖体rna揭示变异度高的地区常见的结构特点
A Comparison of the Crystal Structures of Eukaryotic and
Bacterial SSU Ribosomal RNAs Reveals Common
Structural Features in the Hypervariable Regions
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Jung C. Lee* , Robin R. Gutell*
Center for Computational Biology and Bioinformatics, Institute for Cellular and Molecular Biology, and Section of Integrative Biology, The University of Texas at Austin,
Austin, Texas, United States of America
Abstract
While the majority of the ribosomal RNA structure is conserved in the three major domains of life – archaea, bacteria, and
eukaryotes, specific regions of the rRNA structure are unique to at least one of these three primary forms of life. In particular,
the comparative secondary structure for the eukaryotic SSU rRNA contains several regions that are different from the
analogous regions in the bacteria. Our detailed analysis of two recently determined eukaryotic 40S ribosomal crystal
structures, Tetrahymena thermophila and Saccharomyces cerevisiae, and the comparison of these results with the bacterial
Thermus thermophilus 30S ribosomal crystal structure: (1) revealed that the vast majority of the comparative structure model
for the eukaryotic SSU rRNA is substantiated, including the secondary structure that is similar to both bacteria and archaea
as well as specific for the eukaryotes, (2) resolved the secondary structure for regions of the eukaryotic SSU rRNA that were
not determined with comparative methods, (3) identified eukaryotic helices that are equivalent to the bacterial helices in
several of the hypervariable regions, (4) revealed that, while the coaxially stacked compound helix in the 540 region in the
central domain maintains the constant length of 10 base pairs, its two constituent helices contain 5+5 bp rather than the
6+4 bp predicted with comparative analysis of archaeal and eukaryotic SSU rRNAs.
Citation: Lee JC, Gu
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