中试生产放大经验（Amplification experience in pilot production）.docVIP

中试生产放大经验（Amplification experience in pilot production） The details of the test process all should be considered before 1., did not pay attention to production, to track, in order to find the cause of the problem, another is to communicate with the factory technicians, after all their production experience than you rich. The 2. key is to do the test when we consider the possible problems in the production test, the amplification effect for different reaction the influence of different factors, such as the heterogeneous reaction to consider the stirring effect after amplification, and an endothermic or exothermic reaction, you should consider the problem of heat transfer, they should do some the experiment in the lab to do the extreme effects of the size. 3. it is important to keep samples of each step in the production so that the next step can be analyzed! 4., from my experience in production, the general direct amplification factors are not many, mainly due to improper consideration. The difference between the test and production mainly has two aspects, one is the time factor, the general production process time than was long, estimation of each operation step with the needs of the time, and then in the laboratory, try to simulate the production situation, repeat. The key point is to investigate the effects of different times on the reaction. On the other hand, it is the mass transfer factor, especially the reaction with different phases. This difference may be greater. There are also exothermic reactions that will be more apparent in production. Special attention should be paid to some products which are easy to fly. Also, the separation of materials can sometimes vary greatly, and sometimes all the processes are smooth, very consistent with the small test process, but in the end there is a problem of filtration or drying. Very angry. 5., as far as possible comprehensive consideration, raw materials to be tested, checked, raw materials, familiar with the nature, w