药理学18（Pharmacology 18）.docVIP

药理学18（Pharmacology 18） Lesson 18 Teaching methods: (Please tick tick) theory class discussion class - Experiment - - - other exercises Class arrangement: 2 hours Subject (chapter, section, or topic): Chapter twenty-first calcium antagonists Teaching aims and requirements (three levels of mastery, familiarity and understanding): 1. to master the type and molecular structure of calcium channels and the classification of calcium channel blockers. 2. to master the pharmacological action and clinical application of calcium channel blocker. 3. to master the function, characteristics and application of calcium channel blockers. Teaching emphases and difficulties: 1. the physiological function of calcium ion, the type and molecular structure of calcium channel. Classification, function and clinical application of 2. calcium antagonists. 3. commonly used calcium antagonist diltiazem, nifedipine, Vera Pammy? Flunarizine, function characteristics and application of nimodipine. The molecular structure of 1. calcium channels. Classification, principle of action and clinical application of 2. calcium channel blockers. 3. Vera Pammy, diltiazem, nifedipine, flunarizine? Effect, characteristic and application of nimodipine. Basic content of teaching Calcium antagonists are drugs that selectively block Ca2+, the voltage dependent calcium channel on the cell membrane, into the cell and reduce intracellular Ca2+ concentration, thereby affecting cell function, also known as calcium channel blockers. Section 1 calcium and calcium channels I. physiological significance of calcium ions Two, the type of calcium channel They are divided into two categories according to the activation methods. (I) receptor regulated calcium channel (ROC); (two) voltage dependent calcium channel (VDC); According to its conductance value and dynamic characteristics, it can be divided into L-, T-, N-, P-, Q-, R- and other subtypes. In the cardiovascular system, L- and T- calcium channels are the main types, and