药理学问答（Pharmacology ask）.docVIP

药理学问答（Pharmacology ask） Questions and answers 1, SMZ and TMP compatibility benefits? Answer: SMZ (sulfamethoxazole) and TMP (TMP) inhibited the synthesis of dihydrofolate acid, which inhibits dihydrofolate reductase, a combination of double block folate metabolism of bacteria. At the same time, the two drugs peak plasma concentration is similar to that of the antibacterial effect of synergistic effect, and even the emergence of bactericidal effect, and can reduce the emergence of resistant strains, the clinical use of compound sulfamethoxazole tablets, which is composed of the two drugs, each containing SMZ400mg, TMP80mg. 2 、 compare the mechanism and clinical difference between chlorpromazine and aspirin (aspirin) in the mechanism of cooling Answer: (1) cooling effect: the former reduces fever, body temperature, so that the normal body temperature is slightly lower; the latter reduces fever, body temperature, no effect on normal body temperature. (2): the former cooling mechanism of inhibition of hypothalamic thermoregulation in the coffin, the temperature regulation failure, so that the body temperature change with temperature and lifting; the latter treatment concentration can inhibit PG synthase (cyclooxygenase), reduced the synthesis of PG. (3): the clinical application of sedation, antipsychotic, analgesic, antipyretic, strengthen the role of central inhibitor, artificial hibernation therapy agent, gigantism; the analgesic and anti rheumatism, headache, muscle pain, toothache, neuralgia, dysmenorrhea and cold fever, acute rheumatism, rheumatoid arthritis, prevent thrombosis, treatment of ischemic heart disease, used in angioplasty, bypass, tcia. 3. Briefly describe the principle of increasing the efficacy of propranolol combined with nitroglycerin in the treatment of angina pectoris and the points for attention in its application Combined treatment of angina pectoris, on ventricular volume, ejection time, myocardial contractility, heart rate and other aspects