注射用美洛西林钠说明书（Mezlocillin Sodium for Injection manual）.docVIP

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注射用美洛西林钠说明书（Mezlocillin Sodium for Injection manual）.doc

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注射用美洛西林钠说明书（Mezlocillin Sodium for Injection manual）

注射用美洛西林钠说明书（Mezlocillin Sodium for Injection manual） [Mezlocillin Sodium for Injection] common name [chemical name] (2S, 5R, 6R) -3,3- two (R) -2[3- methyl -6-[(methylsulfonyl) -2- oxo -1- imidazolidine carbamyl]-2- benzene acetyl]-7- oxo -4- -1- dithia aza bicyclo [3.2.0]- heptane -2- acid sodium salt [molecular formula] C21H24N5NaO8S2 [molecular weight] 561.56 [specifications] calculated by C21H25N5O8S2 (1) 0.5g (2) 1.0g [English name] MEZLOCILLIN, SODIUM, FOR, INJECTION [Pinyin name] ZHUSHEYONG MEILUOXILINNA [drug category] penicillins [character] this product is white or white powder or crystalline or loose lump. [pharmacological toxicology] this product is a semi synthetic penicillins antibiotics on Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, proteus, enterobacter, Citrobacter spp., Sarre, Acinetobacter and penicillin sensitive gram positive cocci were used as antibacterial, bactericidal effect of large dose. In Escherichia coli, enterobacter, Klebsiella pneumoniae, Citrobacter sp., Sarre and Acinetobacter etc. the strong antibacterial activity to carbenicillin, ampicillin; of indole positive bacillus proteus, Pseudomonas aeruginosa better antibacterial activity than carbenicillin and sulbenicillin against gram positive bacteria; such as methicillin-resistant Staphylococcus aureus antibacterial activity and carbenicillin and similar antibacterial activity against Streptococcus faecalis than resistant to carbenicillin, methyl benzyl superior. It has good antibacterial activity to most anaerobic bacteria, such as bacteroides. The in vitro tests showed that its production of bacteria (lactamase instability). This product has a significant synergistic effect with gentamicin, kanamycin and other aminoglycoside antibiotics. [adult] pharmacokinetics of intravenous injection of 1g of the product 2G, 15 minutes after the average plasma concentration was 53.4 (g/ml, 152 (g/ml, 1 hours were 12.8 (g/ml, 47.8 (g/ml, 6 hours have not measured blood conc