急性心肌梗死危险因素探讨和叶酸对同型半胱氨酸水平影响.pdfVIP

Discussion of the Risk Factors of Acute Myocardial Infarction and Effects of Folic Acid on Homocysteine Levels Abstract Objective Through inquiring in full the age,gender,family history,the history of smoking and drinking,body weight,body height,the history of hypertension disease and diabetes of the patients,and checking the levels of blood glucose,blood fat and plasma homocysteine(Hcy), to discuss the risk factors and the states of coronary artery pathological changes of acute myocardial infarction(AMI) in middle-age and young patients ; to understand the relation of the plasma Hcy levels and the morbility of AMI ; to determine the role of folic acid in the plasma Hcy levels in the patients. Methods The middle-age and young patient group comprised 21 AMI patients who were less than or equal to 60 years old. The old patient group comprised 30 AMI patients who were greater than or equal to 60 years old, otherwise,the control group was composed of 22 patients who were removed the diagnosis of coronary artery disease （CAD）.The risk factors and the states of coronary artery pathological changes were analyzed in two groups of AMI patients.All 73 patients took 5mg of folic acid every day for 12 weeks.drew blood before and after the treatment.The plasma Hcy levels were measured by using enzyme-labeled immunosorbent assay(ELISA). Then observed the change of the plasma Hcy levels before and after the treatment,and understood the relation of the plasma Hcy levels and the morbility of AMI and the effect of the gender on the plasma Hcy levels. Results 5 1. The pairing Chi-square test showed that male,the family history of early onset CAD ,excessive smoking,excessive drinking and hyperhomocysteinemia were concerned with middle- age and young AMI patients(p0.0