35醋酸甲羟孕酮在子宫内膜不典型增生治疗作用中的研究.docVIP

醋酸甲羟孕酮在子宫内膜不典型增生治疗作用中的研究 【摘要】 目的：探讨醋酸甲羟孕酮在子宫内膜不典型增生中的治疗效果。方法：将104例子宫内膜不典型增生患者随机分为A,B,C三组，其中A组患者（34例）使用醋酸甲羟孕酮治疗1mg/d，B组患者（34例）使用醋酸甲羟孕酮治疗2mg/d，C组患者（34例）口服戊酸雌二醇片1mg/d。患者连续服用药物3-6个月。治疗后观察患者疾病的缓解情况，并使用超声诊断子宫内膜厚度，用药前后月经或阴道出血情况进行PBAC评分表记录并进行统计学分析。结果：用药后三组患者症状均有不同程度的缓解，其中B组治疗缓解率与其他另外两组对比疗效有统计学差别。PBAC评分中对比发现B对改善患者阴道出血情况有很大的作用，其与另外两组结果对比有统计学差别。结论：醋酸甲羟孕酮治疗子宫内膜不典型增生具有显著疗效，且醋酸甲羟孕酮价格较低，适合于患者的长期治疗。 【关键词】醋酸甲羟孕酮；子宫内膜不典型增生； The healing effect Of medroxyprogesterone acetate in endometrial atypical hyperplasia treatment Objective: To investigate the healing effect Of medroxyprogesterone acetate in endometrial atypical hyperplasia treatment.Method: 104 cases of endometrial hyperplasia patients were randomly divided into A, B, C groups, The group A (34 cases) treated with medroxyprogesterone acetate 1mg / d, group B (34 cases) using Estradiol valerate tabletes of 2mg / d, group C(34 cases) of medroxyprogesterone acetate1mg / d. Patients taking drugs for 3-6 months. To observation the patients’ healing effect after treatment, and to use the ultrasound diagnosis to detect endometrial thickness, and measure the vaginal bleeding PBAC score before and after treatment；The result used analyzed statistically. Result: Symptoms after treatment in three groups have different levels of mitigation, The effect of group B was better than the other two groups,the results were statistically different. PBAC score in comparison found bleeding in patients B has a significant improvment , There were statistically different compared with the results of the other two groups. Conclusion: Medroxyprogesterone acetate for endometrial atypical hyperplasia have a significant effect, and medroxyprogesterone acetate has low prices, is suitable for long-term treatment. 【Keyword】Medroxyprogesterone acetate; Endometrial atypical hyperplasia 子宫内膜不典型增生(atypical endometrial hyperplasia, AEH)是指腺体增生并伴随有细胞不典型的情况，属于子宫内膜癌的癌前病变，长期雌激素的刺激可能是其主要发病因素，而其中有23%的子宫内膜不典型增生可以发展成为癌变[1]。既往处理多选用子宫切除术，此类手术虽然相对有效，但是相对于年轻患者来说，子宫的切除影响了患者的生育能力，因此往