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19 2 Vol. 19, No. 2 2007 4 Chinese Bulletin of Life Sciences Apr., 2007 1004-0374(2007)02-0224-09 510632 (autoinducer) Q935; Q936 A Advances in studies of quorum-sensing autoinducer and its inhibitors GUO Jialiang, CHEN Weimin* (Department of Medicinal Chemistry, Jinan University School of Pharmacy, Guangzhou 510632, China) Abstract: Communication among bacteria with quorum-sensing system is accomplished through the exchange of signal molecules called autoinducers. When the densities of autoinducers rise to a certain degree, bacteria respond by specialized gene expression such as biofilm, bioluminescence, virulence and sporulation. Recently many quorum sensing inhibitors, which specifically interfere with the QS circuit, were discovered or synthesized. Detailed review regarding the autoinducer, inhibitors, significance and prospect of bacterial quorum-sensing system has been presented in this paper. Key words: quorum sensing; autoinducer; inhibitor QS Ti (AI)(QSI) Fuqua [1] (quorum sensing, QS)[1] 20 70 1(AI) 2006-10-17 2006-12-14 ( 1 9 8 0 ) ( 1 9 6 3 ) * T e l: 020-mail: twmchen@jnu.edu.cn 225 1 Fuqua [8] (autoinducer AI pheromon)[