肌肉溶解综合症（Lysis syndrome）.docVIP

肌肉溶解综合症（Lysis syndrome） The pathophysiology and diagnosis of rhabdomyolysis: Su Lei, Meng Fansu Chinese Journal of emergency medicine, 2007, eleventh Rhabdomyolysis (rhabdomyolysis, RM) refers to a series of factors affecting striated muscle cell membrane, membrane channel and its energy supply of multiple genetic or acquired diseases resulting in striated muscle injury. The change of cell membrane integrity, the leakage of cellular contents, including myoglobin (myoglobin, Mb), creatinekinase (creatine pphos-phokinases, CPK) and other enzymes, ions and small molecules of toxic substances, often accompanied by the threat of metabolic disorders and acute renal failure life (ARF). In 1881 Fleche first reported by muscle caused by compression of rhabdomyolysis after 1970s reported stroke, poisoning and infection causes of non traumatic rhabdomyolysis (NRM). 1 etiology Rhabdomyolysis caused by trauma has been referred to as gap syndrome and crush syndrome. Compartment syndrome refers to a limb due to trauma or by local performance after extrusion osteofascial compartment pressure caused by increased muscle ischemia; and crush syndrome refers to systemic muscle injury caused by the direct flow of trauma or ischemia - reperfusion. Broadly speaking, rhabdomyolysis is caused by destruction of skeletal muscles leading to release of cell contents into the blood and excretion of urine. In addition to trauma factors, non traumatic factors, including genetic etiology, excessive exercise, muscle extrusion, ischemic metabolic abnormalities, extreme body temperature, drugs, poisons, infections, and other factors can lead to rhabdomyolysis. 1.1 trauma Any major cause of muscle damage or ischemia can lead to rhabdomyolysis, including direct and indirect injuries. 1.2 non traumatic Although rhabdomyolysis was first found in trauma patients, rhabdomyolysis, at least, is more than 5 times more traumatic than rhabdomyolysis. (1) excessive exertion due to impaired substrate utilization or