糖皮质激素的作用（The role of glucocorticoids）.docVIP

糖皮质激素的作用（The role of glucocorticoids） The effects of GCS are different at different doses and concentrations; not only are there differences in quantity, but also qualitative differences. At small doses or physiological levels, physiological effects are mainly produced, and pharmacological effects are produced at high doses or high levels of hyper physiological levels. Physiological function 1, glucose metabolism: promote gluconeogenesis and glycogen synthesis, inhibition of sugar aerobic oxidation and anaerobic glycolysis, and make blood sugar increase way to reduce, antecedents, increase blood sugar. 2, protein metabolism: promote protein decomposition, inhibit its synthesis, forming a negative nitrogen balance. GCS can improve the activity of proteolytic enzyme, promote various tissues (lymph and muscle, skin, bone and connective tissues) in the decomposition of protein, amino acids and retention in the liver into glucose and glycogen and reduced protein synthesis. 3, promote fat decomposition, inhibit its synthesis. It activates the subcutaneous lipase in the limbs, breaks down fat and distributes it to the face, neck, and trunk. 4, water and salt metabolism: MCS effect is weak, the retention of sodium excretion of potassium medical education network collected | finishing. Cause hypocalcemia, but also increase glomerular filtration rate and antagonize the antidiuretic effect of ADH. pharmacological action High doses or high concentrations produce the following pharmacological effects. 1, anti-inflammatory effect: GCS has a rapid, powerful and not specific anti-inflammatory effect. Effective for all kinds of inflammation. In the early stage of inflammation, GCS inhibits telangiectasia, reduces exudation and edema, inhibits infiltration and phagocytosis of white blood cells, and relieves inflammatory symptoms. In the later stage of inflammation, the proliferation of capillary and fibroblast is inhibited and the formation of granulation tissue is delayed. And allev