第十六章 骨髓增生性疾病及其实验诊断（The sixteenth chapter is myeloproliferative disease and its experimental diagnosis）.docVIP

第十六章 骨髓增生性疾病及其实验诊断（The sixteenth chapter is myeloproliferative disease and its experimental diagnosis） The sixteenth chapter is myeloproliferative disease and its experimental diagnosis ? This chapter centers 1. diagnosis of polycythemia vera experimental diagnosis of 2. bone marrow fibrosis experiment 3. essential thrombocythemia experimental diagnosis of polycythemia vera in laboratory diagnosis of 1. concepts: polycythemia vera is a myeloproliferative disease of unknown cause of erythroid hyperplasia. 2. characteristics of hemogram and myelogram (1) blood: the blood is dark purple, red blood cell number [(7 ~ 10) * 1012/L] (180g ~ 240g/L) increased hemoglobin, hematocrit increased (0.54 ~ 0.80), reticulocyte percentage does not increase. Red blood cell morphology normal, slightly uneven size, polychromatic and basophilic stippling erythrocyte increased, occasionally nucleated red blood cells. The number of leukocytes increased (12~15) x 109/L, and a few patients reached 50 * 109/L. The classification mainly consisted of neutrophils, the nucleus shifted left, eosinophils and basophils a little more, and in the blood slices there were young and immature granulocytes. The increase of platelet was up to (400~500) * 109/L. Neutrophil alkaline phosphatase increased. (2) bone marrow: occasional dry pumping phenomenon, the marrow is deep red, there are obvious proliferation of nuclear cells, three lines are hyperplasia, red proliferation is obvious. Megakaryocytes can pile up. The ratio and morphology of each stage were approximately normal. Iron loss or disappearance of bone marrow. 3. other examinations: increased blood volume (normal l50% to 300%), increased red cell capacity (32ml/kg), increased blood density (1.075 ~ 1.080), and increased blood viscosity (5~6 times higher than normal). Serum vitamin B12 increased (900 g/ml), ESR decreased, arterial blood oxygen saturation normal, serum iron normal or decreased, and unsaturated iron joint strength normal or increased