第十五章 浆细胞病及其实验诊断（The fifteenth chapter is plasma cell disease and its laboratory diagnosis）.docVIP

第十五章 浆细胞病及其实验诊断（The fifteenth chapter is plasma cell disease and its laboratory diagnosis） The fifteenth chapter is plasma cell disease and its laboratory diagnosis ? In 2. macroglobulin this chapter 1. test laboratory diagnosis of multiple myeloma, a laboratory diagnosis of multiple myeloma diagnosis experiment of 1. concepts: multiple myeloma (MM) is a single bone marrow plasma cell abnormal proliferation of a malignant tumor, which belongs to the mature B cell tumor. Its characteristic is monoclonal plasma cell hyperplasia and produce monoclonal immunoglobulin, monoclonal plasma cells in the bone marrow hyperplasia and bone marrow involvement, bone destruction, bone pain or fracture, anemia, hypercalcemia, renal dysfunction and abnormal immune function. 2. blood picture: most patients have different degrees of anemia, anemia severity with the progress of the disease and aggravating. Anemia is mostly positive cells, pigmented, a small number of low pigment, there are large cell sex. Red blood cells are usually rouleaux arrangement, the erythrocyte sedimentation rate was also faster. The number of white blood cells is normal or low. The cause of the decrease of WBC is related to the damage of bone marrow. In the leucocyte classification, the lymphocyte relative increase, may occupy 40% to 55%. Bone marrow tumor cells can be seen in peripheral blood slices, mostly from 2% to 3%. If the tumor cells exceed 20% and the absolute value exceeds 2 * 109 / L, the diagnosis of plasma cell leukemia can be considered. The number of platelets is normal or low. Thrombocytopenia is associated with bone marrow infiltration and thrombosis. 3. bone marrow aspiration: bone marrow biopsy is of decisive importance for the diagnosis of the disease. In the early stage, the tumor cells can be focally distributed, so it is necessary to have multiple sites and multiple punctures to help the diagnosis. The tumor cells are often piled up in the tail of the smear. The bone marrow is usually pr