第一节mods概论（Section 1 Introduction to MODS）.docVIP

第一节mods概论（Section 1 Introduction to MODS） Section 1 Introduction Multiple organ dysfunction (syndrome) refers to acute diseases (MODS) In the course of a disease, two or more than two organs or systems develop dysfunction at the same time or in sequence. It was called multiorgan failure (multiple, organ, failure, MOF) or multisystem organ failure (multiple, system, organ, failure), (MSOF) as the consequence of severe infection. With the progress of research on the pathogenesis, it is now recognized, The pathogenesis of MODS is systemic inflammatory response syndrome (systemic, inflammatory, response, syndrome), SIRS) can also be induced by non infectious diseases and can be reversed if it is treated in a timely and reasonable manner. Therefore, MODS is highly regarded by all doctors. However, to date, the pathogenesis of this disease has not been fully understood and effective The treatment is still under investigation. The cause of any systemic inflammatory response is MODS, which is common in surgical diseases, 1. sepsis caused by various surgical infections; 2. severe trauma, burns or major surgery resulting in blood loss and dehydration; 3., various causes of shock, heartbeat, respiratory arrest, resuscitation; 4. ischemia and reperfusion injury of limbs, large areas of tissues or organs caused by various reasons; 5. acute abdomen complicated with necrosis or infection of viscera; 6. blood transfusion, infusion, medication or mechanical ventilation; 7. patients with certain diseases are more likely to develop MODS, such as chronic diseases of the heart, liver and kidney, diabetes mellitus, and immunity Hypofunction, etc. The pathogenesis is not yet fully understood. According to different etiological factors, the pathogenesis is slightly different. However, it has been recognized The involvement of cytokines in various inflammatory mediators exacerbates SIRS and leads to the development of MODS. The intestinal tract acts as a repository for bacteria, causing int