盐酸莫西沙星氯化钠注射液（Moxifloxacin hydrochloride and sodium chloride injection）.docVIP

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盐酸莫西沙星氯化钠注射液（Moxifloxacin hydrochloride and sodium chloride injection）.doc

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盐酸莫西沙星氯化钠注射液（Moxifloxacin hydrochloride and sodium chloride injection）

盐酸莫西沙星氯化钠注射液（Moxifloxacin hydrochloride and sodium chloride injection） Moxifloxacin Hydrochloride and Sodium Chloride Injection (Moxifloxacin, Hydrochloride, and, Injection, Sodium, Chloride, etc) (Bai Fule) The main ingredient of this product is moxifloxacin hydrochloride. The chemical name is 1-, propyl -7-{(S, S), -2, 8- diazo - bicyclic [4.3.0], nonyl -8- group,}-6- fluoride, -8- methoxy -1, 4- two hydrogen, -4- oxygen, -3- quinoline carboxylic acid hydrochloride. [traits] This product is yellowish and transparent liquid. [pharmacology and toxicology] 1. pharmacological effects (1) mechanism of action Moxifloxacin is a 8- methoxy fluoroquinolone antibacterial agent with broad-spectrum activity and bactericidal activity. Moxifloxacin showed a broad spectrum of antimicrobial activity against gram positive bacteria, gram negative bacteria, anaerobic bacteria, acid fast bacteria, and atypical microorganisms such as Mycoplasma, chlamydia and legionella. The mechanism of bactericidal action was interference with topoisomerase II and IV. Topoisomerase is the key enzyme that controls the DNA topology and is involved in DNA replication, repair, and transcription. Moxifloxacin showed a concentration dependent bactericidal activity. The minimum bactericidal concentration and minimum inhibitory concentration were basically the same. Moxifloxacin is also effective against beta lactam and macrolide resistant bacteria. Through the experimental animal model of infection, moxifloxacin proved to be highly active in vivo. (2) drug resistance Drug resistance to penicillins, cephalosporins, aminoglycosides, macrolides, and tetracyclines does not affect the antimicrobial activity of moxifloxacin. There is no cross resistance between moxifloxacin and these antimicrobial agents. Plasmid mediated resistance has not been detected so far. The 8- methoxy group of moxifloxacin has low selectivity for Gram-positive bacteria and high activity and resistance mutations in comparison with 8- hyd