甲基化（Methylation）.docVIP

甲基化（Methylation） DNA methylation can cause heterochromatin of DNA and inhibit the gene expression on the segment DNA. The structural gene contains many CpG structures, and the 5 carbon atoms of the two cytosine in 2CpG and 2GPC are usually methylated, and the two methyl groups exhibit a specific three-dimensional structure in the large double stranded DNA structure. In genomes, 60% to 90% of CpG is methylated, and the methylated CpG cluster into CpG islands, located at the core sequence of the structural gene promoter and at the transcription start point. Experiments have shown that hypermethylation of repressor transcription proceeds. DNA methylation can cause qualitative changes in the structure of the corresponding region of staining genome, lose DNA ribozyme? Restriction endonuclease cleavage sites and sensitive sites of enzyme DNA, the chromatin is highly condensed into a spiral, group, loss of transcriptional activity. 5 C methylation of cytosine deamination to generate thymine, which may lead to replacement of the gene mutation, nucleotide mismatch: T2G, if not corrected in the process of cell division, can cause genetic disease or cancer, and biological methylation is stable and heritable. Methylation English Name: Methylation Methylation refers to the process of transferring methyl catalysis to other compounds from reactive methyl compounds (such as S-, methionine, methionine). A variety of methyl compounds can be formed, or some proteins or nucleic acids are chemically modified to form methylated products. Edit the function of this paragraph methylation Methylation is an important modification of proteins and nucleic acids, and down regulate the expression of genes associated with many diseases, cancer, aging, Alzheimers disease, is one of the important research content of epigenetics. The most common methylation modifications are DNA methylation and histone methylation. DNA methylation shuts down the activity of certain genes and demethylation induces the