牙周组织（Periodontium）.docVIP

牙周组织（Periodontium） (a) The main methods of periodontal tissue engineering is cultured with high concentration and functional activity of cell associated with good biocompatibility in plant extracellular matrix materials and biodegradable, in under the action of growth factor, After a period of culture, the complex of cells and biomaterials was implanted in periodontal lesion, to form a new with the original special function and morphology of periodontal tissues, to repair and restore the function of. Growth factor associated with periodontal tissue engineering include basic fibroblast growth factor, bone inducing protein, enamel matrix protein, insulin-like growth factor, platelet-derived growth factor and transforming growth factor beta. In the repair of periodontal tissues, different kinds of growth factors have a dose-dependent effect on the synthesis ability of periodontal cells, and they have selective chemotaxis to periodontal tissues and can regulate and promote the restoration of periodontal tissues. The commonly used seed cells in periodontal tissue engineering are periodontal ligament cells, bone marrow stromal stem cells, embryonic stem cells, periodontal ligament stem cells and so on. Among them, periodontal ligament stem cells are newly found adult stem cells which can be used in periodontal tissue engineering, By inducing differentiation, the structure of the periodontal membrane and cementum complex can be formed, so as to achieve the true periodontal tissue regeneration. Conclusion: the study of seed cells will be one of the focuses in the future of periodontal tissue engineering, As a newly discovered periodontal tissue engineering seed stem cell, periodontal ligament stem cells have become a hot spot in the research of periodontal tissue engineering because of their unique properties and closely related to periodontal tissues, It has been widely used in periodontal tissue engineering. (two) Objective: to isolate and purify human periodontal ligamen