Signal, Noise, and Detection Limits in Mass （信号、噪声和检测质量的限制）.pdfVIP

Signal, Noise, and Detection Limits in Mass Spectrometry Technical Note Chemical Analysis Group Authors Abstract Greg Wells, arry Prest, and In the past, the signal-to-noise of a chromatographic peak determined from a single Charles William Russ IV, measurement has served as a convenient figure of merit used to compare the perfor- Agilent Technologies, Inc. mance of two different MS systems. Design evolution of mass spectrometry instru- 2850 Centerville Road mentation has resulted in very low noise systems that have made the comparison of Wilmington, DE 19809-1610 performance based upon signal-to-noise increasingly difficult, and in some modes of USA operation impossible. This is especially true when using ultra-low noise modes such as high resolution mass spectrometry or tandem MS; where there are often no ions in the background and the noise is essentially zero. Statistical methodology commonly used to establish method detection limits for trace analysis in complex matrices as a means of characterizing instrument performance is shown to be valid for high and low background noise conditions. Introduction Instrument detection limit (IDL)