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Experimental models for studying mucociliary (为研究黏膜纤毛的实验模型)
Eur Respir J 1998; 11: 222–228 Copyright ERS Journals Ltd 1998 DOI: 10.118398 European Respiratory Journal Printed in UK - all rights reserved ISSN 0903 - 1936 SERIES AIRWAY MUCUS Edited by P.K. Jeffery Number 7 in this Series Experimental models for studying mucociliary clearance M. King Experimental models for studying mucociliary clearance. M. King. ERS Journals Ltd Pulmonary Research Group, University of 1998. Alberta, Edmonton, AB T6G 2S2, Canada. ABSTRACT: Respiratory tract mucus is a viscoelastic gel, the rheological prop- erties of which are determined mainly by its content of mucous glycoproteins and Correspondence: M. King Pulmonary Research Group water. The rheology and quantity of mucus, in concert with ciliary factors, are the University of Alberta major determinants of mucociliary clearance. Edmonton A wide range of animal models for studying the secretion and clearance of mucus AB T6G 2S2 are available. Ex vivo models, such as the frog palate or excised bovine trachea, Canada provide direct, meaningful data regarding the clearability of mucus. Rodent mod- Fax: 001 403 4924878 els of chronic bronchitis, based on irritant
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