体外循环致先天性心脏病手术患者血液细胞因子水平….PDFVIP

维普资讯 l4 · 1一门 ChinJClinThoracCardiova~~sI．rgF·ebrasry．1998，Vo1．5一No．1 体外循环致先天性心脏病手术患者 ④ 肖锝傻 【摘要】 目的 探讨体外循环对先天性心脏扁手术患者外罔血细胞因子水平的影响．方法 以先天性心脏病 手术患者为研究对象。不需体外循环舯心血管手术患者作为对照，酶联免疫吸附法和生物活性法测定手术前 中 后 多时同点外周血中细鞠因子水平． }砉秉 二组患者术中和／或术后白细胞介素．2明显降低(Po．05)}可溶性白细 胞介索·2受体 白细胞介素 ·6肿窟坏死因子吨和白细胞介素·lo明显升高(Po．05)． 结论 手术应擞和体外循环 均是引起先天性心畦寨患者术中和 ／或术后细胞日子水平改变的主要因素． 关【键调】生 些兰必 苎 塑 塑堕里 TheI~MtllgU ofCytokiau LevelsRelatedtoCradlopalmonsryByps~ inPatlenlsUndergonigSurgerytarCoagenHal HeartDefects XiaaX西H -ZhangChongfie,ZAaoZongrong，eta1．DivisicmofCardiothorocS~rgeryandDepart． 删∞lo，j聃啪啪 口‘∞ ，1ir‘ Chino,Unkversit~ofMedicalScie~es-Chcngdu610041-P．R．China [A~Wact] 0bJecUve Toexaminetheeffect cardiopulmonarybrpass{CPB)oncytokineslevelsofperipheral blond inpatientsundergoing surgeryforcongenitalheartdefects． MethodJ T epossibledifferencesbetween∞ ． tientsundergoing aurgeryforcongenitalheartdejects(CPBgroup，n 10)andthose~ceivingclosureofpatentdue． tusarteroisusorpericardoictomy(no-CPBgroup，n 9)were evalusted．Venousbloodlevelsofinterleukin．2(IL．2)， solubleinterleakin·2 ceptor(s11．·2R)，interleukin·6(1L．6)。tumornecros~ faetor．n(TNF )-andinterleukin．10(1L． 10)were measuredbyme8i~1ofbiologicalactivityassayorenzyme-linked immunosorbentassaysatmuhiplet；me pointsbeof丁e·during，jndafteroperation． Resulta As “ p redwithpre--operativevalues。IL．2levelsdecreased significantlyinbothgroups (P0．05)，and thelevehofsIL-2R，IL-6-TNF-a，IL．1nincreasedsignificantlyinbo th groupsatmultipletimepointsa~teroperation(PO—O1)．Althoughthere nopre~operativedifferencesinthese cytoldnae betweenthe twogroups(P0．05)，thepost-operativechangesofcytokinesinCPBgroupW|lBmo obvi． oust