neofunctionalization in vertebrates the example of retinoic acid receptors视黄酸受体的neofunctionalization脊椎动物的例子.pdfVIP
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neofunctionalization in vertebrates the example of retinoic acid receptors视黄酸受体的neofunctionalization脊椎动物的例子
Neofunctionalization in Vertebrates: The Example of Retinoic Acid Receptors 1¤a ´ 1[ 2[ 1¤b 3 Hector Escriva , Stephanie Bertrand , Pierre Germain , Marc Robinson-Rechavi , Muriel Umbhauer , ´ ˆ 3 1 4 2 1* Jerome Cartry , Marilyne Duffraisse , Linda Holland , Hinrich Gronemeyer , Vincent Laudet ´ 1 Structure and Evolution of Nuclear Hormone Receptors, UMR 5161 du CNRS, INRA LA 1237, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 BioSciences Lyon- ´ ´ ´ ´ ` Gerland, Ecole Normale Superieure de Lyon, Lyon, France, 2 Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP/College de France, BP ´ ´ 163, Illkrich, CU de Strasbourg, France, 3 UMR CNRS 7622, Biologie du Developpement, Case 24, Universite Pierre et Marie Curie, Paris, France, 4 Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies. Data on evolutionary changes in gene expression (i.e., evolution of transcription factor-cis-regulatory elements relationships) tell only part of the story; protein function, best studied by biochemical and funct
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