gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with ccl4-induced fibrosis肠道微生物群失调与炎症和细菌易位与ccl4-induced纤维化小鼠.pdfVIP

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gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with ccl4-induced fibrosis肠道微生物群失调与炎症和细菌易位与ccl4-induced纤维化小鼠.pdf

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gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with ccl4-induced fibrosis肠道微生物群失调与炎症和细菌易位与ccl4-induced纤维化小鼠

Gut Microbiota Dysbiosis Is Associated with Inflammation and Bacterial Translocation in Mice with CCl4-Induced Fibrosis ´ 1,2 3 ´ 4 1,2 ´ 1 Isabel Gomez-Hurtado , Arlette Santacruz , Gloria Peiro , Pedro Zapater , Ana Gutierrez , Miguel ´ 1 3 ´ ´ 1,2 Perez-Mateo , Yolanda Sanz , Ruben Frances * ´ ´ ´ 1 Unidad Hepatica, Hospital General Universitario, Alicante, Spain, 2 CIBERehd, Instituto de Salud Carlos III, Madrid, Spain, 3 Instituto de Agroquımica y Tecnologıa de ´ ´ Alimentos (IATA), Consejo Superior de Investigaciones Cientıficas (CSIC), Valencia, Spain, 4 Unidad de Investigacion, Hospital General Universitario, Alicante, Spain Abstract Background: Gut is the major source of endogenous bacteria causing infections in advanced cirrhosis. Intestinal barrier dysfunction has been described in cirrhosis and account for an increased bacterial translocation rate. Hypothesis and Aims: We hypothesize that microbiota composition may be affected and change along with the induction of experimental cirrhosis, affecting the inflammatory response. Animals and Methods: Progressive liver damage was induced in Balb/c mice by weight-controlled oral administration of carbon tetrachloride. Laparotomies were performed at weeks 6, 10, 13