functional genetic variants in dc-signr are associated with mother-to-child transmission of hiv-1功能基因变异dc-signr与hiv - 1病毒的母婴传播.pdfVIP

Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1 ` 1,2 1 3 4 Genevieve Boily-Larouche , Anne-Laure Iscache , Lynn S. Zijenah , Jean H. Humphrey , Andrew J. 5 6 1,2 Mouland , Brian J. Ward , Michel Roger * ´ ´ ´ ´ ´ ´ 1 Laboratoire d’Immunogenetique, Centre de Recherche du Centre Hospitalier de l’Universite de Montreal (CRCHUM), Montreal, Canada, 2 Departement de Microbiologie ´ ´ ´ et Immunologie, Universite de Montreal, Montreal, Canada, 3 Department of Immunology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe, 4 Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, 5 Department of Medicine, The Lady Davis Institute for Medical Research and McGill AIDS Center, McGill University, Montreal, Canada, 6 Research Institute of the McGill University Hospital Complex, Montreal, Canada Abstract Background: Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/ lymph node–specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and is expressed at the maternal-fetal interface, we hypothesized that it could influence MTCT of HIV-1. Methods and Findings: To investigate the potential role of DC-SIGNR in MTCT of HIV-1, we carrie