found the elusive antar transcription antiterminator发现难以捉摸的安塔尔转录antiterminator.pdfVIP

Perspective Found: The Elusive ANTAR Transcription Antiterminator 1 2 Valley Stewart *, Herman van Tilbeurgh * ´ 1 Department of Microbiology, University of California Davis, Davis, California, United States of America, 2 IBBMC-CNRS UMR8619, Universite Paris-Sud, Orsay, France Regulated transcription termination Although different ANTAR proteins antiterminator to enable transcription provides an efficient and responsive means use a variety of signal input domains, at readthrough. (Indeed, restriction sites in- to control gene expression [1]. Intrinsic least half contain a two-component signal troduced into the nasF operon leader [16] terminators, which consist of an RNA transduction receiver domain [6,11]. Re- destroy the P2 structure, explaining the stem-loop followed by a poly-U tract, ceiver function is governed through phos- resultant uninducible phenotype.) catalyze termination by disrupting the phorylation and dephosphorylation by a To test this model, Ramesh et al. first RNA polymerase elongation complex cognate signal-responsive sensor kinase constructed a variety of site-specific alter- [2]. In antitermination, an antiterminator [17]. For example, the ethanolamine- ations in the eutP leader, and confirmed stem-loop is mutually exclusive with the responsive EutW sensor kinase controls the subelements important for EutV terminator stem-loop [1,3]. In different the EutV respo