flotillins are involved in the polarization of primitive and mature hematopoietic cellsflotillins参与原始和成熟的造血细胞的极化.pdfVIP

Flotillins Are Involved in the Polarization of Primitive and Mature Hematopoietic Cells 1,2,3 4,5 6,7 8 Lawrence Rajendran *, Julia Beckmann , Astrid Magenau , Eva-Maria Boneberg , Katharina 6,7 9 4,5 2,8,10 Gaus , Antonella Viola , Bernd Giebel *, Harald Illges * 1 Systems and Cell Biology of Neurodegeneration, Department of Psychiatry Research, University of Zurich, Zurich, Switzerland, 2 Immunology, University of Konstanz, Konstanz, Germany, 3 Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, 4 Institute for Transplantation Diagnostics and Cellular ¨ ¨ ¨ Therapeutics, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany, 5 Institute of Transfusionsmedicine, Transplantations Diagnostics, Universitatsklinikum Essen, Essen, Germany, 6 Centre for Vascular Research, University of New South Wales, Sydney, Australia, 7 Department of Haematology, Prince of Wales Hospital, Sydney, Australia, 8 Biotechnologie Institut Thurgau, Taegerwilen, Switzerland, 9 Department of Biomedical Sciences, University of Padova, Padova, Italy, 10 Immunology and Cell Biology, University of Applied Sciences, Rheinbach, Germany Abstract Background: Migration of mature and immature leukocytes in response to chemokines is not only essential during inflammation and host defense, but also during development of the hematopoietic system. Many molecules implicated in migratory polarity show