a tractable experimental model for study of human and animal scabies易处理的实验模型研究人类和动物的疥疮.pdfVIP

A Tractable Experimental Model for Study of Human and Animal Scabies 1,2 1 3 1,4 1 1 Kate Mounsey , Mei-Fong Ho , Andrew Kelly , Charlene Willis , Cielo Pasay , David J. Kemp , 1 1 James S. McCarthy , Katja Fischer * 1 Queensland Institute of Medical Research and Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Brisbane, Queensland, Australia, 2 Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia, 3 Department of Employment, Economic Development and Innovation, Centre for Advanced Animal Science, University of Queensland, Gatton, Queensland, Australia, 4 Griffith Medical Research College, a joint program of Griffith University and the Queensland Institute of Medical Research, QIMR, Herston, Queensland, Australia Abstract Background: Scabies is a parasitic skin infestation caused by the burrowing mite Sarcoptes scabiei. It is common worldwide and spreads rapidly under crowded conditions, such as those found in socially disadvantaged communities of Indigenous populations and in developing countries. Pruritic scabies lesions facilitate opportunistic bacterial infections, particularly Group A streptococci. Streptococcal infections cause significant sequelae and the increased community streptococcal burden has led to extreme levels of acute rheumatic fever and rheumatic heart disease in Australia’s Indigenous communities. In addition, emerging resistance to currently available therapeuti