a systematic review of studies that aim to determine which outcomes to measure in clinical trials in children系统回顾研究旨在确定的结果来衡量儿童临床试验中.pdfVIP

PLoS MEDICINE A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children 1* 1 1 2 Ian Sinha , Leanne Jones , Rosalind L. Smyth , Paula R. Williamson 1 Institute of Child Health, University of Liverpool, Liverpool, United Kingdom, 2 Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom Funding: Ian Sinha is funded by the A B S T R A C T Department of Health. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the Background manuscript. In clinical trials the selection of appropriate outcomes is crucial to the assessment of whether Competing Interests: The authors one intervention is better than another. Selection of inappropriate outcomes can compromise have declared that no competing the utility of a trial. However, the process of selecting the most suitable outcomes to include interests exist. can be complex. Our aim was to systematically review studies that address the process of Academic Editor: David Moher, selecting outcomes or outcome domains to measure in clinical trials in children. Children’s Hospital of Eastern Ontario Research Institute, Canada Methods and Findings Citation: Sinha I, Jones L, Smyth RL, Williamson PR (2008) A systematic We searched Cochrane databases (no date restrictions) in December 2006; and MEDLINE review of studies that aim to determine which outcomes to (1950 to 2006), CINAHL (