有哪些信誉好的足球投注网站a safe vaccine (dv-stm-07) against salmonella infection prevents abortion and confers protective immunity to the pregnant and new born mice安全的疫苗(dv-stm-07)对沙门氏菌感染预防堕胎和授予保护性免疫的怀孕和新出生的老鼠.pdfVIP
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a safe vaccine (dv-stm-07) against salmonella infection prevents abortion and confers protective immunity to the pregnant and new born mice安全的疫苗(dv-stm-07)对沙门氏菌感染预防堕胎和授予保护性免疫的怀孕和新出生的老鼠
A Safe Vaccine (DV-STM-07) against Salmonella Infection
Prevents Abortion and Confers Protective Immunity to
the Pregnant and New Born Mice
Vidya Devi Negi, Arvindhan G. Nagarajan, Dipshikha Chakravortty*
Centre for Infectious Disease Research and Biosafety Laboratories, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
Abstract
Pregnancy is a transient immuno-compromised condition which has evolved to avoid the immune rejection of the fetus by
the maternal immune system. The altered immune response of the pregnant female leads to increased susceptibility to
invading pathogens, resulting in abortion and congenital defects of the fetus and a subnormal response to vaccination.
Active vaccination during pregnancy may lead to abortion induced by heightened cell mediated immune response. In this
study, we have administered the highly attenuated vaccine strain DpmrG-HM-D (DV-STM-07) in female mice before the
onset of pregnancy and followed the immune reaction against challenge with virulent S. Typhimurium in pregnant mice.
Here we demonstrate that DV-STM-07 vaccine gives protection against Salmonella in pregnant mice and also prevents
Salmonella induced abortion. This protection is conferred by directing the immune response towards Th2 activation and
Th1 suppression. The low Th1 response prevents abortion. The use of live attenuated vaccine just before pregnancy carries
the risk of transmission to the fetus. We have shown that this vaccine is safe as the vaccine strain is quickly eliminated from
the mother and is not transmitted to the fetus. This vaccine also confers immunity to the new born mice of vaccinated
mothers. Since there is no evidence of the vaccine candidate reaching the new born mice, we hypothesize that it may be
due to trans-colostral transfer of protective anti-Salmonella antibodies. These r
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