a research agenda for malaria eradication vaccines根除疟疾疫苗的研究议程.pdfVIP

Review A Research Agenda for Malaria Eradication: Vaccines The malERA Consultative Group on Vaccines * that vaccine development efforts need to pay attention to Abstract: Vaccines could be a crucial component of Plasmodium species other than P. falciparum, especially Plasmodium efforts to eradicate malaria. Current attempts to develop vivax, if malaria eradication is to be achieved. malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity Rationale of the Proposed malERA Approach to and mortality. Continued support for these efforts is essential, but if malaria vaccines are to be used as part of a Development of Malaria Vaccines repertoire of tools for elimination or eradication of First, we introduce the broad concept of VIMT. VIMT may be malaria, they will need to have an impact on malaria composed of one or more of the following components: classical transmission. We introduce the concept of ‘‘vaccines that TBVs that target sexual and mosquito stage parasite antigens; interrupt malaria transmission’’ (VIMT), which includes not highly effective pre-erythrocytic vaccines that reduce asexual and only ‘‘classical’’ transmission-blocking vaccines that target sexual stage parasite prevalence rates; hi