a randomized controlled phase iib trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis b patientsiib阶段随机对照试验抗原抗体免疫原性复杂的慢性乙型肝炎患者的治疗性疫苗.pdfVIP

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a randomized controlled phase iib trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis b patientsiib阶段随机对照试验抗原抗体免疫原性复杂的慢性乙型肝炎患者的治疗性疫苗.pdf

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a randomized controlled phase iib trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis b patientsiib阶段随机对照试验抗原抗体免疫原性复杂的慢性乙型肝炎患者的治疗性疫苗

A Randomized Controlled Phase IIb Trial of Antigen- Antibody Immunogenic Complex Therapeutic Vaccine in Chronic Hepatitis B Patients 1 2 1 3 4 5 6 Dao-Zhen Xu , Kai Zhao , Li-Min Guo , Xin-Yue Chen , Hui-Fen Wang , Ji-Ming Zhang , Qin Xie , Hong 7 8 9 10 11 12 13 2 Ren , Wen-Xiang Wang , Lan-Juan Li , Min Xu , Pei Liu , Jun-Qi Niu , Xue-Fan Bai , Xin-Liang Shen , Zheng-Hong Yuan14, Xuan-Yi Wang14,15, Yu-Mei Wen14* 1 Ditan Hospital, Beijing, China, 2 Beijing Institute of Vaccine and Biological Products, Beijing, China, 3 You-An Hospital, Capital Medical University, Beijing, China, 4 302 Military Hospital, Beijing, China, 5 Hua-Shan Hospital, Fudan University, Shanghai, China, 6 Rui-Jin Hospital, Shanghai Jiaotong University, Shanghai, China, 7 Second affiliated hospital, Chongqing Medical University, Chongqing, China, 8 First affiliated hospital, Chongqing Medical University, Chongqing, China, 9 First affiliated hospital, Zhejiang University, Hanzhou, Zhejiang Province, China, 10 Guangzhou Eighth Hospital, Guangzhou, Guangdong Province, China, 11 Second Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, China, 12 First affiliated hospital, Jilin University, Changchun, Jilin Province, China, 13Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi Province, China, 14 Key Laboratory Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai, China, 15 Institute of Biological Sciences, Fudan University, Shanghai, China Abstract Background: The safety of the immune complexes composed of yeast-derived hepatitis B surface