a myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin vi in the stereocilia of mammalian inner ear hair cellsmyo6突变破坏肌凝蛋白之间的协调,揭示新功能的肌球蛋白vi在哺乳动物内耳毛细胞静纤毛.pdfVIP
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a myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin vi in the stereocilia of mammalian inner ear hair cellsmyo6突变破坏肌凝蛋白之间的协调,揭示新功能的肌球蛋白vi在哺乳动物内耳毛细胞静纤毛
A Myo6 Mutation Destroys Coordination between the
Myosin Heads, Revealing New Functions of Myosin VI in
the Stereocilia of Mammalian Inner Ear Hair Cells
1.¤a 1. 2. 1 3 4
Ronna Hertzano , Ella Shalit , Agnieszka K. Rzadzinska , Amiel A. Dror , Lin Song , Uri Ron ,
5 1 6 5¤b 4
Joshua T. Tan , Alina Starovolsky Shitrit , Helmut Fuchs , Tama Hasson , Nir Ben-Tal , H. Lee
3 6,7 2 1
Sweeney , Martin Hrabe de Angelis , Karen P. Steel , Karen B. Avraham *
1 Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel, 2 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus,
Hinxton, Cambridge, United Kingdom, 3 Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America,
4 Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, 5 Section of Cell and Developmental Biology, University of
¨
California San Diego, La Jolla, California, United States of America, 6 Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of
Experimental Genetics, Neuherberg, Germany, 7 Technical University of Munich, Munich, Germany
Abstract
Myosin VI, found in organisms from Caenorhabditis elegans to humans, is essential for auditory and vestibular function in
mammal
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