a molecular epidemiology survey of respiratory adenoviruses circulating in children residing in southern palestine儿童呼吸道腺病毒传播的分子流行病学调查居住在南部巴勒斯坦.pdfVIP

A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine 1 2 1 1 Lina Qurei , Donald Seto , Zaidoun Salah , Maysa Azzeh * 1Virology Research Laboratory, Medical Research Center, Al-Quds University , East Jerusalem-Abu Dies, Palestine, 2 School of Systems Biology, George Mason University, Manassas, Virginia, United States of America Abstract A molecular epidemiology survey was performed in order to establish and document the respiratory adenovirus pathogen profiles among children in Southern Palestine. Three hundred and thirty-eight hospitalized pediatric cases with adenovirus- associated respiratory tract infections were analyzed. Forty four cases out of the 338 were evaluated in more detail for the adenoviruses types present. All of the children resided in Southern Palestine, that is, in city, village and refugee camp environments within the districts of Hebron and Bethlehem. Human adenoviruses circulated throughout 2005–2010, with major outbreaks occurring in the spring months. A larger percent of the children diagnosed with adenoviral infections were male infants. DNA sequence analysis of the hexon genes from 44 samples revealed that several distinct adenovirus types circulated in the region; these were HAdV-C1, HAdV-C2, HAdV-B3 and HAdV-C5. However, not all of these types were detected within each year. This is the first study ever conducted in Palestine of the genetic epidemiology of respiratory adenovirus infections. Citation: Qurei L, Seto D, Salah Z, Azzeh M (2012) A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine. PLoS ONE 7(8): e42732. doi:10.1371/journal.pone.0042732 Editor: Eric J. Kremer, French National Centre for Scientific Res