有哪些信誉好的足球投注网站a full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors一个完整的药理分析三个土耳其与人类β-adrenoceptorsβ-adrenoceptors和比较.pdfVIP
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a full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors一个完整的药理分析三个土耳其与人类β-adrenoceptorsβ-adrenoceptors和比较
A Full Pharmacological Analysis of the Three Turkey b-
Adrenoceptors and Comparison with the Human b-
Adrenoceptors
Jillian G. Baker*
Wellcome Trust Clinician Scientist Fellow, Institute of Cell Signalling, University of Nottingham, Nottingham, United Kingdom
Abstract
Background: There are three turkey b-adrenoceptors: the original turkey b-adrenoceptor from erythrocytes (tbtrunc, for
which the X-ray crystal structure has recently been determined), tb3C and tb4C-receptors. This study examined the
similarities and differences between these avian receptors and mammalian receptors with regards to binding characteristics
and functional high and low affinity agonist conformations.
Methodology/Principal Findings: Stable cell lines were constructed with each of the turkey b-adrenoceptors and 3H-
CGP12177 whole cell binding, CRE-SPAP production and 3H-cAMP accumulation assays performed. It was confirmed that
the three turkey b-adrenoceptors are distinct from each other in terms of amino acid sequence and binding characteristics.
The greatest similarity of any of the turkey b-adrenoceptors to human b-adrenoceptors is between the turkey b3C-receptor
and the human b2-adrenoceptor. There are pharmacologically distinct differences between the binding of ligands for the
tbtrunc and tb4C and the human b-adrenoceptors (e.g. with CGP20712A and ICI118551). The tbtrunc and tb4C-
adrenoceptors appear to exist in at least two different agonist conformations in a similar manner to that seen at both the
human and rat b1-adrenoceptor and human b3-adrenoceptors. The tb3C-receptor, similar to the human b2-adrenoceptor,
does not, at least so far, appear to exist in more than one agonist conformation.
Conclusions/Significance: There are several similarities, but also se
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