有哪些信誉好的足球投注网站a focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function聚焦原位杂交的屏幕识别候选人转录监管机构胸腺上皮细胞的发育和功能.pdfVIP
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a focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function聚焦原位杂交的屏幕识别候选人转录监管机构胸腺上皮细胞的发育和功能
A Focused In Situ Hybridization Screen Identifies Candidate Transcriptional Regulators of Thymic Epithelial Cell Development and Function Qiaozhi Wei, Brian G. Condie* Department of Genetics, University of Georgia, Athens, Georgia, United States of America Abstract Background: Thymic epithelial cells (TECs) are necessary for normal T cell development. Currently, one transcription factor, Foxn1 is known to be necessary for the progression of fetal TEC differentiation. However, some aspects of fetal TEC differentiation occur in Foxn1 mutants, suggesting the existence of additional transcriptional regulators of TEC differentiation. The goal of this study was to identify some of the additional candidate transcription factors that may be involved in the specification and/or differentiation of TECs during fetal development. Methodology/Principal Findings: We identified candidate fetal TEC transcriptional regulators via data and text mining. From our data mining we selected the transcription factors Foxg1, Isl1, Gata3, Nkx2-5, Nkx2-6 and Sox2 for further studies. Whole mount in situ hybridizations confirmed the expression of these transcription factors within subdomains of the third pharyngeal pouch from E9.5–E10.5. By E11.5 days Foxg1 and Isl1 transcripts were the only mRNAs from this group of genes detected exclusively within the thymus domain of the third pouch. Based on this initial in situ hybridization analysis, we focused on defining the expression of Foxg1 and Isl1 during multiple stages of thymus development and TEC differentiation. We found that Foxg1 and Isl1 are specifically expressed in differentiating TECs during fetal and postnatal stages of thymus development. In addition, we found differential expression of Islet1 and Foxn1 within the fetal and postnatal TEC population. Conclusions/Significanc
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